Yes, you can. And if you do not have the Quick Keys, you can assign the function to the Pen button or one of the buttons at the top center of your Pen Tablet. 

This will allow you to keep your hands on your Quick Keys and off the keyboard. 

[1] Open your Xencelabs Settings panel, and select the Quick Keys from the left-hand navigation column.

[2] Click on the button you want to assign it to. In this case, I have selected button One.

Select Application > [3] from here select File Explere.