The Xencelabs Quick Keys is designed to work with the Xencelabs line of products and needs to have the Xencelabs Driver installed to work.
With that said, it will also work with your Wacom tablets and displays on macOS and Windows 10 platforms once you have installed our Xencelabs driver.
For Wacom users on the Windows 10 platform that have applications that use WinTabs, you will need to know that only one device can connect to Wintabs at a time. If the last device you used was your Wacom tablet, you would need to disconnect the USB cable for the Wacom tablet from your computer. Then you will be able to use your Xencelabs tablet with that application.
The WinTab issue will only affect Windows users using Xencelabs and Wacom tablets and applications that use the WinTab feature instead of Windows Ink.
If you are using a tablet other an a Wacom tablet, I would suggest that you save your preference files if you have the ability to do that within your other tablet's driver.
Your Xencelabs Driver will work with most other tablet drivers. You will want to be cognisant of backing your other driver's data up before installing the Xencelabs Driver. If you are not using the other tablet anymore, remove the other driver altogether.