Are you using the Xencelabs Quick Keys or the Pen Tablet? How is the Xencelabs device connected to your Mac? Are you using a USB hub, and is it powered (it has a wall power) or passive (no wall power)?
If you turn your Xencelabs device Off and then back on. Does this help?
trippsf@mac.com
After wake from sleep, I get the message "Please connect..." and the pad is unresponsive.
If I then re-install the Mac driver, the quick keys becomes responsive.